There was no significant difference between Tyrode and DMSO, and their effect did not differ from the baseline (p>0.999). ATG decreased the frequency of contractions in a dose-dependent manner, manifested by the increased period time [Fig. 4].; 20 µM ATG and 40 µM ATG showed an observable increased period time characterised by an alteration in spontaneous contraction [Fig. 2]. After 15 and 30 min, 40 µM ATG had higher activity than Tyrode, DMSO, 10 µM ATG, 20 µM ATG and 10 µM TGN (p˂ 0.0001). ButHowever, increasing the concentration of ATG from 1 µM to 10 µM did not lead to a significant increase in activity (p> 0.999) [ Fig. 4].
Likewise, (TGN) increased the contraction period in a dose-dependent manner. After 15 and 30 min, 20 µM TGN had higher activity than Tyrode, DMSO, 10 µM ATG, 20 µM ATG and 10 µM TGN (p˂ 0.05)
.; 20 µM TGN was also marked by an alteration of spontaneous contraction that becomebecame clear after 30 min [Fig. 2]. Though there was an observable increase after treatment with 10 µM TGN, it was not significantly different from 0.5 µM TGN and 1 µM TGN and (p> 0.999).
Comparatively, there was no difference between 10 µM ATG and 10 µM TGN (p>0.05).
ButHowever, 20 µM TGN, had higher activity than 20 µM ATG (p˂0.05) and was comparable to 40 µM ATG over the same period (p> 0.05) [Fig.4].
CNQX, AP5, propranol plus phentolamine and LNAME had no effect (p>0.999). The activity of 0.5 µM nifedipine was higher than 1 µM ATG, 10 µM ATG, 0.5 µM TGN, 1 µM TGN and 10 µM TGN, (p˂0.05) [ Fig. 4]
.; 1 µM nifedipine abolished the phasic contractions, which waswere reversed after 15 min of washout with Tyrode’s solution [Fig. 2].

The text above was approved for publishing by the original author.

Previous       Next

נסו בחינם

אנא הכנס את הודעתך
אנא בחר באיזו שפה לבצע את התיקון

בדקו את הAPI שלנו לשירותי הגהה.

eAngel.me

eAngel.me is a human proofreading service that enables you to correct your texts by live professionals in minutes.